• Reduce text

    Reduce text
  • Restore text size

    Restore text size
  • Increase the text

    Increase the text
  • Print

    Print
Modeling gene regulation networks in multi-cellular systems during seed maturation
Reference
1557737030
Deadline for applications
06/30/2019
Date of publication
05/13/2019

Details

Details on the type of contract
Postdoctoral contract
Duration of contract
18 months, with extension possible
Beginning
07/01/2019

Remuneration
Depending on experience

Assignment

Name of unit of assignment
UMR1318 IJPB Institut Jean-Pierre BOURGIN
Address of unit of assignment
INRA Versailles route de Saint-Cyr RD 10 78026 VERSAILLES CEDEX
Region of assignment
Paris Region

Description

Working environment

The LabEx SPS (Saclay Plant Sciences ; https://www6.inra.fr/saclay-plant-sciences) is seeking highly motivated and talented candidates to join a project on the modeling of gene regulation networks during seed maturation.

Seed maturation is a key developmental phase during which seeds accumulate storage products and progressively acquire resistance to dessication. This phase is controlled by a few master genes (including the “LAFL” genesLEC1,ABI3,FUS3, andLEC2) that exhibit specific spatio-temporal expression patterns at the tissue scale. Our objective is to develop a computational modeling approach to decipher the determinants and regulations underlying these patterns. Based on bibliographical, transcriptomic, and imaging data already available on wild-type and mutant genotypes in the model plantArabidopsis thaliana, the project is to design, implement and analyze computational models of the master gene regulation network in a multi-cellular framework.

The selected candidate will join the Modeling and Digital Imaging team and will work in collaboration with the Development and Seed Quality team at the Institut Jean-Pierre Bourgin (IJPB ; http://www-ijpb.versailles.inra.fr). IJPB, one of the largest research centers in Plant Sciences in Europe, gathers a unique ensemble of experimental resources and pluridisciplinary expertise in biology, chemistry and modeling. IJPB is located near Paris in the INRA Versailles-Grignon research center, next to the gardens of the Royal Palace of Versailles.

Keywords. Transcriptional regulation, GRN modeling, network inference and analysis, multicellular systems, seed maturation.

Contact
Philippe Andrey (philippe.andrey@inra.fr)
Bertrand Dubreucq (bertrand.dubreucq@inra.fr)

Training and skills required

The candidates should have a strong background and expertise in computational biology and/or applied mathematics, with a PhD or equivalent, and a real motivation or experience for working in a multi-disciplinary context. Experience in the computational modeling of GRN and/or multi-cellular morphogenetic models would be much appreciated.

Contact

Name
Philippe Andrey
Telephone
01 30 83 33 50
Email
Philippe.andrey@inra.fr