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Modeling gene regulation networks in multi-cellular systems during seed maturation
Deadline for applications
Date of publication


Details on the type of contract
Postdoctoral contract
Duration of contract
18 months, with extension possible

Depending on experience


Name of unit of assignment
UMR1318 IJPB Institut Jean-Pierre BOURGIN
Address of unit of assignment
INRA Versailles route de Saint-Cyr RD 10 78026 VERSAILLES CEDEX
Region of assignment
Paris Region


Working environment

The LabEx SPS (Saclay Plant Sciences ; https://www6.inra.fr/saclay-plant-sciences) is seeking highly motivated and talented candidates to join a project on the modeling of gene regulation networks during seed maturation.

Seed maturation is a key developmental phase during which seeds accumulate storage products and progressively acquire resistance to dessication. This phase is controlled by a few master genes (including the “LAFL” genesLEC1,ABI3,FUS3, andLEC2) that exhibit specific spatio-temporal expression patterns at the tissue scale. Our objective is to develop a computational modeling approach to decipher the determinants and regulations underlying these patterns. Based on bibliographical, transcriptomic, and imaging data already available on wild-type and mutant genotypes in the model plantArabidopsis thaliana, the project is to design, implement and analyze computational models of the master gene regulation network in a multi-cellular framework.

The selected candidate will join the Modeling and Digital Imaging team and will work in collaboration with the Development and Seed Quality team at the Institut Jean-Pierre Bourgin (IJPB ; http://www-ijpb.versailles.inra.fr). IJPB, one of the largest research centers in Plant Sciences in Europe, gathers a unique ensemble of experimental resources and pluridisciplinary expertise in biology, chemistry and modeling. IJPB is located near Paris in the INRA Versailles-Grignon research center, next to the gardens of the Royal Palace of Versailles.

Keywords. Transcriptional regulation, GRN modeling, network inference and analysis, multicellular systems, seed maturation.

Philippe Andrey (philippe.andrey@inra.fr)
Bertrand Dubreucq (bertrand.dubreucq@inra.fr)

Training and skills required

The candidates should have a strong background and expertise in computational biology and/or applied mathematics, with a PhD or equivalent, and a real motivation or experience for working in a multi-disciplinary context. Experience in the computational modeling of GRN and/or multi-cellular morphogenetic models would be much appreciated.


Philippe Andrey
01 30 83 33 50